Fig. 1

mBDNF to proBDNF Ratio. Ratio of mBDNF to proBDNF at ZT4 and ZT12, in tPA^−/− and tPA^+/+ mice. There is a significant (p < 0.05) main effect of genotype, with tPA^−/− mice having a reduced ratio compared to tPA^+/+ mice. All groups have a sample size of 3. Error bars represent standard error of the mean