Figure 4

Mitochondrial dysfunction suggested by elevated TCA cycle intermediates and 2-hydroxybutyrate (AHB) at T c,Max . (A) Fold-change from control in biochemicals implicated in the TCA cycle. (B) The TCA cycle, with red circles indicating biochemicals with significant deviation from control after heat stress. *p < 0.05 heat exposed versus control rat, two-way ANOVA with contrasts.