Figure 1

Altered metabolic pathways and process networks in plasma of rats after heat stress. Biochemicals were grouped by KEGG super-pathway and sub-pathway. Pathways meeting significance thresholds were plotted by number of affected metabolites per total number identified in the plasma (at right). Significance thresholds were determined by ANOVA, by ratio of heat/control at Tc,Max, 24 or 48Â hours. The 48Â hour endpoint was further subdivided into injured or uninjured animals by cardiac histopathology.